Dolutegravir Resistance and Failure in a Kenyan Patient

New dolutegravir resistance pattern identified in a patient failing antiretroviral therapy

INTRODUCTION The most recently approved antiretroviral, the integrase inhibitor dolutegravir (DTG), is described to be a very potent drug with a unique resistance profile, but a certain degree of cross-resistance to RAL or EVG induced drug resistance, which is mediated mainly by integrase mutations at positions 140 and 148. The impact of a single N155H mutation to DTG resistance is described to...

Hypotensive response after resistance exercise leading to failure and not to failure in trained men

Hypertension is epidemic disease which post-exercise hypotension (PEH) is useful strategies for hypertension. The aim of present study was to investigate the effects of resistance exercise leading to failure (REF) and resistance exercise not to failure (NREF) on PEH phenomenon in trained men. Eight trained men (age: 22.12±1.81 yr; height: 179±3.44 cm; weight: 73.82±4.29 kg;...

Pattern of congestive heart failure in a Kenyan paediatric population

BACKGROUND Heart failure in children is a common cause of morbidity and mortality, with high socio-economic burden. Its pattern varies between countries but reports from Africa are few. The data are important to inform management and prevention strategies. OBJECTIVE To describe the pattern of congestive heart failure in a Kenyan paediatric population. METHODS This was a retrospective study ...

A de novo Reciprocal X; 9 Translocation in A Patient with Premature Ovarian Failure

passivity in waiting for godot and endgame: a psychoanalytic reading

this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...